Table 3 Differential metabolites in caffeine metabolism, primary bile acid biosynthesis, steroid hormone biosynthesis, and glycerophospholipid metabolism of the control vs. LGTB group.

From: Analysis of the potential regulatory mechanisms of female and latent genital tuberculosis affecting ovarian reserve function using untargeted metabolomics

Metabolites

Expression

VIP(OPLS-DA)

P value

FC

Pathways

LysoPC (22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)

Decreased

1.6412

0.009328

0.978

Glycerophospholipid metabolism

LysoPC (20:4(5Z,8Z,11Z,14Z)/0:0)

Decreased

1.1411

0.04129

0.9881

Glycerophospholipid metabolism

Cortisol

Decreased

1.7534

0.01143

0.9638

Steroid hormone biosynthesis

PG (20:4(5Z,8Z,11Z,14Z)/20:2(11Z,14Z))

Increased

3.8661

0.04618

1.3

Glycerophospholipid metabolism

LysoPC (P-18:0/0:0)

Decreased

1.0213

0.02249

0.9901

Glycerophospholipid metabolism

Glycocholic Acid

Decreased

3.0297

0.007655

0.9008

Primary bile acid biosynthesis

20alpha-Hydroxycholesterol

Decreased

1.188

0.02849

0.9815

Steroid hormone biosynthesis

3a, 7a-Dihydroxy-5b-cholestane

Decreased

1.4133

0.01437

0.9746

Primary bile acid biosynthesis

3-Methylxanthine

Decreased

1.0337

0.01536

0.9806

Caffeine metabolism

1-Methylxanthine

Decreased

1.0214

0.02194

0.9811

Caffeine metabolism

11-Epicortisol

Decreased

1.5712

0.008384

0.966

Steroid hormone biosynthesis

  1. The variable importance of projection (VIP) value was obtained from the OPLS-DA analysis. Generally, metabolites with VIP ≥ 1 are considered to have significant differences. The P value was obtained from the Student's t-test, and metabolites with P value < 0.05 are generally considered to have significant differences. Fold Change (FC) was obtained from univariate analysis.
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