Table 3 Assessment of the characteristic parameters of each biomarker for predicting POP.
Blood-based biomarkers | Cutoff point | AUC (95% CI) | ACC (%, 95% CI) | SEN (%, 95% CI) | SPE (%, 95% CI) | PPV (%, 95% CI) | NPV (%, 95% CI) |
|---|---|---|---|---|---|---|---|
Single biomarkers | |||||||
WBC | 7.650 | 0.584 (0.530–0.638) | 41.1 (41.1–41.2) | 76.9 (69.3–84.6) | 37.5 (34.7–40.3) | 11.0 (8.9–12.2) | 94.2 (92.2–96.3) |
NEU | 5.890 | 0.606 (0.554–0.659) | 46.2 (46.2–46.2) | 79.5 (72.2–86.8) | 42.9 (40.0–45.7) | 12.3 (9.9–14.6) | 95.4 (93.6–97.2) |
Glucose | 6.150 | 0.628 (0.572–0.682) | 51.3 (51.3–51.3) | 73.5 (65.5–81.5) | 49.1 (46.2–51.9) | 12.7 (10.2–15.2) | 94.8 (93.1–96.6) |
ALB | 38.070 | 0.707 (0.663–0.751) | 57.3 (57.3–57.3) | 83.8 (77.7–90.4) | 54.6 (51.8–57.5) | 15.7 (12.8–18.5) | 97.1 (95.8–98.4) |
Combinations | |||||||
WBC*NEU | 47.670 | 0.598 (0.545–0.652) | 47.5 (47.4–47.5) | 75.2 (67.4–83.0) | 44.7 (41.8–47.5) | 12.0 (9.7–14.4) | 94.7 (92.8–96.6) |
WBC*Glucose | 58.400 | 0.680 (0.630–0.730) | 61.6 (61.6–61.6) | 69.2 (60.9–77.6) | 60.8 (58.0–63.6) | 15.1 (12.1–18.1) | 95.2 (93.6–96.7) |
WBC/ALB | 0.225 | 0.656 (0.604–0.709) | 54.8 (54.8–54.8) | 76.1 (68.3–83.8) | 52.7 (49.8–55.5) | 13.9 (11.2–16.6) | 95.6 (94.0–97.2) |
NEU*Glucose | 37.215 | 0.681 (0.631–0.730) | 47.4 (47.3–47.4) | 85.5 (79.1–91.9) | 43.5 (40.7–46.4) | 13.2 (10.8–15.6) | 96.7 (95.2–98.3) |
NEU/ALB | 0.179 | 0.662 (0.611–0.714) | 58.2 (58.2–58.3) | 70.1 (61.8–78.4) | 57.1 (54.2–59.9) | 14.1 (11.3–16.9) | 95.0 (93.4–96.6) |
GAR | 0.175 | 0.750 (0.710–0.790) | 63.5 (63.5–63.5) | 79.5 (72.2–86.8) | 61.9 (59.1–64.7) | 17.4 (14.1–20.6) | 96.8 (95.5–98.0) |
