Figure 10

An electron micrograph of the ultrastructure of Purkinje cells in the cerebellum of rats. Results shown are from the (A) Saline, (B) HS, (C) HR, (D) HV, and (E) HRV experimental groups. Harmaline significantly altered the ultrastructure of Purkinje cells. The most common ultrastructural findings in harmaline group neurons were cell nuclear shrinkage, chromatin margination, and RER swelling. The ultrastructure of most Purkinje cells was preserved in the HR, HV, and HRV groups. The white arrows indicate intact cells with a distinct nucleus; the gray arrow indicates intact mitochondria; and the black arrows indicate RER swelling in degenerated cells. (4000x). Saline (S), harmaline + Saline (HS), harmaline + Res (HR), harmaline + VitD3 (HV), and harmaline + Res + VitD3 (HRV).