Figure 3 | Scientific Reports

Figure 3

From: Resveratrol and 1,25-dihydroxyvitamin D decrease Lingo-1 levels, and improve behavior in harmaline-induced Essential tremor, suggesting potential therapeutic benefits

Figure 3

Characterization of the animal’s exploratory activity and anxiety-like behavior in the open field test. (A) Frequency of rearing, (B) number of grooming sessions, (C) total distance walked, (D) central zone duration, and (E) peripheral zone duration are shown. On day one, rearing was significantly higher in the HRV compared to the HR group. Additionally, on day one, the HRV and HV groups showed significantly lower grooming in comparison to the HS and HR groups. HRV and HV groups showed a decrease in grooming compared to the HR group on days one and three. The HS group showed a lower TDM in comparison to the Saline group. Data are expressed as the mean ± SD (* in comparison to the harmaline group, ★ in comparison to the HR group). Saline (S), Saline + Res (SR), Saline + VitD3 (SV), Saline + Res + VitD3 (SRV), Ethanol (E), harmaline + Saline (HS), harmaline + Res (HR), harmaline + VitD3 (HV), and harmaline + Res + VitD3 (HRV). Data were not normally distributed are represented as medians with interquartile ranges as a scatter dot plot.

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