Table 3 REs and significant genes identified in major clustering patterns.

From: A comprehensive analysis of spermatozoal RNA elements in idiopathic infertile males undergoing fertility treatment

Trend

Pattern

REs

Significant REs (p < 0.05)

Unique gene IDs (p < 0.05)

Common gene names (p < 0.05)

Increased in high blast rate group

Same-up

1758

31

32

23

Up-up

754

2

2

1

Increased in low blast rate group

Down-same

8948

304

160

138

Down-down

1059

29

9

8

  1. Importantly, the down-same pattern reflects 304 significant REs and 138 RE-associated RNAs (RE-RNAs) which are up-regulated in the low group, compared to both the average and high groups. For the up-up pattern, only one common RE-RNA was found to increase with increasing blastocyst rate (from low to average to high): PPP4R1. In contrast, 8 RE-RNAs decreased with increasing blastocyst rate (from high to average to low): RNA45S1, RNA18S1, RNA5-8S1, RNA28S1, ITGAM, VPS53, COQ8B, and Z82195.3.
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