Table 2 Associations of cGMP with vascular risk factors.

From: Association of natriuretic peptides and receptor activity with cardio-metabolic health at middle age

 

cGMP by Sex and Ethnicity

Mediation

Without NPs

With NPs

ANP

BNP

CNP

Renin

− 0.18

− 0.09

− 0.10

− 0.07

− 0.02

BMI

− 0.18

− 0.21

0.04

0.00

− 0.01

Fat mass

− 0.15

− 0.17

0.02

0.00

− 0.01

HOMA

− 0.23

− 0.19

− 0.04

− 0.07

− 0.01

Triglycerides

− 0.21

− 0.19

0.00

− 0.04

0.00

LDL

− 0.15

− 0.11

− 0.02

− 0.04

− 0.01

Chol/HDL

− 0.22

− 0.18

− 0.01

− 0.04

− 0.01

eGFR

0.01

− 0.07

   
  1. Standardized regression coefficients for cGMP on vascular risk factors adjusted for Sex and Ethnicity with and without ANP, BNP and CNP. Mediation effect of ANP, BNP and CNP on the effect of cGMP on vascular risk factors adjusted for Sex and Ethnicity. Boldface numerals indicate associations with p < 0.05.
  2. BMI, Body mass index; HOMA, Homeostatic Model Assessment for Insulin Resistance; LDL, low-density lipoprotein; Chol/HDL, total-cholesterol to high-density lipoprotein ratio; eGFR, estimated glomerular filtration rate.