Table 2 Fourteen metabolic pathways with significant difference in both the diarrhea and constipation groups as compared to healthy controls.

Pathway	Groups
	CC vs. HC		CD vs. HC
	*p	*p_adj	*p	*p_adj
Amino acid metabolism	< 0.001	0.007	< 0.001	< 0.001
Replication and repair	0.001	0.014	< 0.001	< 0.001
Translation	0.001	0.015	< 0.001	< 0.001
Signal transduction	0.002	0.015	< 0.001	< 0.001
Nucleotide metabolism	0.017	0.049	< 0.001	< 0.001
Metabolism of cofactors and vitamins	0.007	0.026	< 0.001	< 0.001
Metabolism of terpenoids and polyketides	0.011	0.035	< 0.001	< 0.001
Energy metabolism	0.001	0.015	< 0.001	< 0.001
Membrane transport	0.005	0.026	< 0.001	< 0.001
Cell growth and death	0.003	0.019	< 0.001	< 0.001
Folding sorting and degradation	0.005	0.026	< 0.001	< 0.001
Endocrine system	0.003	0.035	< 0.001	< 0.001
Nervous system	0.005	0.026	< 0.001	< 0.001
Neurodegenerative diseases	0.011	0.026	0.001	0.001

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