Table 2 Description of the sample of Dementia individuals in the clusters obtained.

From: Genetic-based patient stratification in Alzheimer’s disease

Variable

Cluster 1

Cluster 2

Cluster 3

Statistic

p-value

Number

11

29

2

NA

NA

Sex (Female)

5 (45.45%)

11 (37.93%)

1 (50.0%)

0.27

0.8753

Education years

14.82 ± 1.95

15.97 ± 2.85

13.50 ± 1.50

1.34

0.2739

Age

70.91 ± 8.77

75.54 ± 8.50

85.25 ± 4.35

2.63

0.0852

APOE E2/E2

0 (0.0%)

10 (34.48%)

1 (50.0%)

5.52

0.0633

APOE E2/E3

0 (0.0%)

1 (3.45%)

0 (0.0%)

0.46

0.7948

APOE E3/E4

6 (54.55%)

15 (51.72%)

1 (50.0%)

0.03

0.9850

APOE E4/E4

5 (45.45%)

3 (10.34%)

0 (0.0%)

6.87

0.0322

Aβ(1–42) (pg/mL)

677.29 ± 399.19

714.13 ± 313.29

499.55 ± 43.55

0.38

0.6875

tTau (pg/mL)

439.24 ± 150.33

359.55 ± 101.03

262.7 ± 51.10

2.59

0.0889

pTau (pg/mL)

44.17 ± 15.49

35.39 ± 11.58

26.06 ± 5.7

2.43

0.1022

AV45

1.39 ± 0.17

1.38 ± 0.23

1.34 ± 0.063

0.04

0.9617

FDG

0.99 ± 0.12

1.02 ± 0.17

1.02 ± 0.08

0.10

0.9095

MRI WholeBrain

0.6305 ± 0.0636

0.666 ± 0.0711

0.6573 ± 0.1054

0.91

0.4109

MRI Ventricles

0.0257 ± 0.0101

0.0357 ± 0.0154

0.0195 ± 0.0000

2.28

0.1168

MRI MidTemp

0.0109 ± 0.0024

0.0118 ± 0.0019

0.0121 ± 0.0016

0.81

0.4550

MRI Hippocampus

0.0035 ± 0.0004

0.0038 ± 0.0007

0.0038 ± 0.0005

0.64

0.5348

MRI Fusiform

0.0100 ± 0.0017

0.0108 ± 0.0016

0.0109 ± 0.0002

0.95

0.3958

MRI Entorhinal

0.0017 ± 0.0003

0.0020 ± 0.0005

0.0023 ± 0.0002

2.18

0.1277

MMSE

22.45 ± 1.72

22.90 ± 2.02

22.50 ± 0.50

0.22

0.8047

CDR-SOB

5.45 ± 1.78

4.07 ± 1.42

4.25 ± 0.75

3.18

0.0523

  1. AV45 Average AV45 (Florbetapir) SUVR of frontal, anterior cingulate, precuneus, and parietal cortex relative to the cerebellum, FDG Average FDG-PET of angular, temporal, and posterior cingulate.