Table 4 The histo-toxicological evaluation of the mouse dorsal skin tissues after 8 h of exposure to fabricated membrane.

From: Designing of a new transdermal antibiotic delivery polymeric membrane modified by functionalized SBA-15 mesoporous filler

Membrane type

Keratin detachment

Epidermis integrity

ICSW*

Lipolysis

Subcutis integrity

M1

3.33 ± 0.236a

1.78 ± 0.147a

2.78 ± 0.147a

2.89 ± 0.261a

1.67 ± 0.167a

M3

2.33 ± 0.167b

1.89 ± 0.111a

2.33 ± 0.167ab

3.00 ± 0.289a

2.56 ± 0.176b

M6

1.56 ± 0.176c

3.22 ± 0.222b

2.00 ± 0.236b

2.11 ± 0.111b

3.00 ± 0.167b

  1. The columns with different superscripts show significant differences between groups.
  2. *ICSW intercellular space widening.