Figure 1
From: The role of RUNX1/NF-κB in regulating PVAT inflammation in aortic dissection
Analysis of in vivo results. (a) Schematic diagram depicting the establishment of an animal model for aortic dissection In vivo experiments were divided into 4 groups with 10 mice in each group. (b) Analysis of qPCR results for RUNX1, NF-κB, MMP-2, and TNF-α in thoracic aortic PVAT of wild-type mice with aortic dissection. (c, d) Analysis of IHC results for RUNX1, F4/80, MMP-2, and TNF-α in thoracic aortic PVAT of wild-type mice with aortic dissection. (e) qPCR analysis of RUNX1, NF-κB, MMP-2, and TNF-α in the thoracic aortic PVAT of RUNX1flox/flox mice with aortic dissection. (f) Results of aorta gross specimens from AD RUNX1flox/flox mice and control mice. When comparing the differences between the two groups, t test was used for analysis if the distribution was normal. When comparing the differences between multiple groups, one-way ANOVA test was used if the distribution was normal and the variance was homogeneous. Data are shown as \(\overline{x}\) ± s. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
