Table 3 Univariate and multivariate analyses with a logistic regression model for the risk of acute exacerbation.

From: Acute exacerbation predicting poor outcomes in idiopathic interstitial pneumonia and advanced lung cancer patients undergoing cytotoxic chemotherapy

 

Univariate (n = 708)

Univariate (N = 397)

Multivariate

N

OR

95% CI

P value

N

OR

95% CI

P value

OR

95% CI

P value

Sex

Female

63

Ref

  

39

Ref

  

Ref

  

Male

645

2.357

0.72–7.718

0.1576

358

2.458

0.572–10.572

0.2268

2.178

0.493–9.619

0.3042

Age

 < 70

299

Ref

  

171

Ref

  

Ref

  

≧ 70

409

1.844

1.082–3.142

0.0245

226

1.531

0.793–2.955

0.2046

1.432

0.721–2.844

0.3051

PS

0

226

Ref

  

133

Ref

  

Ref

  

1

378

0.828

0.467–1.469

0.5197

212

1.05

0.496–2.226

0.898

0.945

0.435–2.053

0.8863

≧ 2

104

1.941

0.991–3.8

0.0531

52

3.025

1.26–7.268

0.0133

2.603

0.992–6.83

0.052

Smoking index

 < 50

345

Ref

         

≧ 50

352

1.01

0.614–1.66

0.9689

       

Clinical diagnosis of IIPs

Not-IPF

294

Ref

         

IPF

406

0.817

0.499–1.337

0.4204

       

HRCT pattern

Inconsistent with the UIP pattern

190

Ref

         

UIP pattern

243

0.975

0.524–1.814

0.9357

       

Possible UIP pattern

275

0.888

0.48–1.641

0.7037

       

History of AE

Presence

11

Ref

         

Absence

689

–

–

0.9839

       

Emphysema

Absence

381

Ref

         

Presence

326

0.788

0.479–1.297

0.3489

       

KL-6

 < 500

184

Ref

  

138

Ref

  

Ref

  

≧ 500,  < 1000

221

1.373

0.697–2.701

0.3592

148

1.165

0.539–2.521

0.6974

1.04

0.466–2.322

0.9229

≧ 1000,  < 2000

124

1.55

0.729–3.299

0.255

87

1.539

0.668–3.547

0.3118

1.292

0.535–3.121

0.5686

≧ 2000

35

1.878

0.635–5.552

0.2546

24

1.374

0.36–5.234

0.6419

1.258

0.317–4.985

0.7442

SP-D

 < 110

203

Ref

         

≧ 110,  < 150

71

1.794

0.78–4.125

0.1692

       

≧ 150,  < 250

80

1.931

0.877–4.252

0.1024

       

≧ 250

52

2.29

0.956–5.485

0.063

       

%FVC

≧ 80

296

Ref

         

≧ 50,  < 80

137

1.014

0.53–1.943

0.9657

       

 < 50

8

–

–

0.9859

       

%DLco

≧ 80

55

Ref

         

 < 80

183

1.656

0.604–4.541

0.327

       

Desaturation on exertion

Absence

418

Ref

  

330

Ref

  

Ref

  

Presence

80

1.765

0.878–3.548

0.111

67

2.032

0.986–4.187

0.0547

1.416

0.622–3.224

0.4077

Treatment for IIPs

No

678

Ref

         

Yes

30

1.855

0.687–5.007

0.2229

       

Histology of lung cancer

SCLC

216

Ref

  

109

Ref

  

Ref

  

NSCLC

492

3.316

1.617–6.803

0.0011

288

3.258

1.249–8.498

0.0158

3.316

1.25–8.8

0.016

  1. AE acute exacerbation, CI confidence interval, %Dlco predicted diffusing capacity of the lung for monoxide, %FVC predicted forced vital capacity, HRCT high-resolution computed tomography, Hx histology, IP interstitial pneumonia, KL-6 Krebs von den Lungen-6, NS not significant, NSCLC non-small cell lung cancer, OR odds ratio, PaO2 partial arterial pressure of oxygen, PS performance status, ref reference, SCLC small cell lung cancer, SP-D surfactant protein-D, UIP usual interstitial pneumonia.
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