Figure 6
From: Follicle-stimulating hormone receptor expression in advanced atherosclerotic plaques
Binding and routes of transport of FSHR1-A02 antibody-colloidal gold particles by the arterial endothelial cells covering atherosclerotic plaques located in the aortic arch of ApoEKO/hFSHR1KI mice. (Panels A through D) After 30 min of circulation in vivo, the tracer particles (black dots) bound to the luminal plasma membrane and clathrin-coated pits were internalized via clathrin-coated vesicles in endosomes, and delivered into the subendothelial space. (Panel E) In contact with macrophages the FSHR1-A02 antibody-colloidal gold particles were internalized via a pathway involving clathrin-coated pits, clathrin-coated vesicles and concentrated in endosomes. (EC, endothelial cell. Scale bar: 200 nm).
