Table 2 Main virulence and antibiotic resistance traits of representative SAB-related S. aureus strains selected for the assays in the G. mellonella infection model.

From: Exploring the virulence potential of Staphylococcus aureus CC121 and CC152 lineages related to paediatric community-acquired bacteraemia in Manhiça, Mozambique

Strain ID

Clonal Complex (CC), (ST)a

PVL encoding genes

Biofilm production phenotype

Mean OD570 value

Median survival time (days) and survival-associated p-value

Resistance profilea

Patients outcomeb

105 inoculum

p-value vs. 105 ATCC25923/RN4220

107 inoculum

p-value vs. 107 ATCC25923/RN4220

ATCC 25923

CC30 (ST243)

 + 

Strong producer

2.134

 > 7

–

1

–

–

–

RN 4220

CC8 (ST8)

−

Strong producer

1.271

 > 7

–

3.5

–

–

–

SA 152

CC121 (ST121)

 + 

Strong producer

1.134

2

 < 0.0001/< 0.0001

1

0.2426/0.0002

Non-MDR

Survived

SA 179

CC121 (ST121)

 + 

Non-producer

0.030

2

 < 0.0001/< 0.0001

1

0.0026/ < 0.0001

Non-MDR

Died

SA 199

CC121 (nd)

 + 

Moderate producer

0.209

2

 < 0.0001/< 0.0001

1

 < 0.0001/ < 0.0001

MDR

Died

SA 243

CC121 (nd)

 + 

Weak producer

0.144

 > 7

0.4843/0.9683

1

0.0026/ < 0.0001

MDR

Survived

SA 352

CC121 (ST121)

−

Non-producer

0.061

3

0.0063/0.0286

1

0.1350/< 0.0001

MDR

Survived

SA 301

CC152 (ST152)

 + 

Non-producer

0.037

2

 < 0.0001/< 0.0001

1

0.0026/< 0.0001

Non-MDR

Survived

SA 302

CC152 (ST52)

−

Strong producer

1.431

2

 < 0.0001/< 0.0001

1

0.0026/< 0.0001

MDR

Survived

SA 324

CC152 (ST152)

 + 

Strong producer

2.024

3

0.0002/0.0230

1

0.0172/< 0.0001

Fully susceptiblec

Survived

SA 330

CC152 (ST152)

 + 

Strong producer

2.158

2

 < 0.0001/ < 0.0001

1

0.0077/< 0.0001

MDR

Survived

SA 343

CC152 (nd)

 + 

Non-producer

0.038

2

 < 0.0001/ < 0.0001

1

0.0026/< 0.0001

Non-MDR

Died

SA 353

CC152 (ST152)

 + 

Strong producer

0.535

2

 < 0.0001/ < 0.0001

1

0.0077/< 0.0001

MDR

Survived

  1. aData from Garrine et al. 2023b16.
  2. bData from Garrine et al., 2023a15.
  3. cFully susceptible to the tested antibiotics (Garrine et al. 2023b)16.
  4. ST sequence type, MDR multidrug-resistant S. aureus (defined as those strains not susceptible to three or more unrelated classes of antibiotic).
  5. Significant differences are highlighted at bold type. nd not determined.
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