Figure 1 | Scientific Reports

Figure 1

From: Hematological and renal toxicity in mice after three cycles of high activity [177Lu]Lu-PSMA-617 with or without human α1-microglobulin

Figure 1

Uptake characteristics of [177Lu]Lu-PSMA-617 changes after each cycle of treatment. Representative SPECT images and graphs of [177Lu]Lu-PSMA-617 activity in male BALB/cAnNRj nude mice. Maximum intensity projections using the NIH color scale windowed to best display kidneys with the top activity noted. Note that the Cycle 2 animal is the one with an outlier kidney. Annotations: k = kidney, and s = standard. (A) Sum of all frames of the dynamic scans immediately p.i. with 90–100 frames of 1 min. (B) Examples of [177Lu]Lu-PSMA-617 kinetics in kidneys as measured using dynamic SPECT imaging directly after injection. Percent of injected activity per gram of kidney (%IA/g) plotted. Chosen animals have typical distribution for their cycles except for the second cycle animal where the high uptake kidney is an outlier.

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