Table 1 Animals co-injected with rA1M receive lower absorbed dose to kidney. Mean injected activity, excluding any activity extravasated in the tail at time of imaging.

From: Hematological and renal toxicity in mice after three cycles of high activity [177Lu]Lu-PSMA-617 with or without human α1-microglobulin

 

Cycle 1

Cycle 2

Cycle 3

Total

Mean injected activity (MBq)

 [177Lu]Lu-PSMA-617 + rA1M

183.6

191.5

183.3

558.4

 [177Lu]Lu-PSMA-617 + PBS

182.9

185.7

194.4

563

Kidney absorbed dose per injected activity (Gy/MBq)

 [177Lu]Lu-PSMA-617 + rA1M

0.052

0.053

0.152

 

 [177Lu]Lu-PSMA-617 + PBS

0.045

0.037 (0.161*)

0.209

 

Mean kidney absorbed dose (Gy)

 [177Lu]Lu-PSMA-617 + rA1M

9.60

10.29

27.78

45.35

 [177Lu]Lu-PSMA-617 + PBS

8.247

6.78 (29.80*)

40.60

55.63 (78.70*)

  1. *Including outlier kidney in cycle 2.
  2. Absorbed dose per injected activity and resulting absorbed dose are each calculated 5 weeks p.i. Note that the values differ substantially whether an outlier kidney in cycle 2 is included or not, thus both results are included.
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