Figure 4 | Scientific Reports

Figure 4

From: Exercise ameliorates muscular excessive mitochondrial fission, insulin resistance and inflammation in diabetic rats via irisin/AMPK activation

Figure 4

Exercise suppresses muscular excessive mitochondrial fission in diabetic rats. (A–C) Immunofluorescence and its semiquantitative analysis for evaluating Drp1 and Fis1 expression in soleus muscle of rats between groups. (D) RT-qPCR analysis of the mRNA expression of Drp1, Fis1, MFF and MFN2 in soleus muscle of rats between groups. (E,F) Western blot analysis of Drp1, Fis1, MFF and MFN2 expression in soleus muscle of rats between groups. Con control, DM Type 2 diabetes, Ex Type 2 diabetes combined with exercise, Drp1 Dynamin-related protein 1, Fis1 Fission protein 1, MFF Mitochondrial fission factor, MFN2 Mitofusin 2. *Denotes the significant difference compared with Con group (p < 0.05); #indicates the significant difference compared with DM group (p < 0.05).

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