Figure 4
Causal association of five different serum metabolites with the risk of developing iridocyclitis. Leave-one-out analysis (A) and scatter plot (B) of the association between tryptophan and iridocyclitis. Leave-one-out analysis (C) and scatter plot (D) of the association between proline and iridocyclitis. Leave-one-out analysis (E) and scatter plot (F) of the association between 3,4-dihydroxybutyrate and iridocyclitis. Leave-one-out analysis (G) and scatter plot (H) of the association between theobromine and iridocyclitis. Leave-one-out analysis (I) and scatter plot (J) of the association between 7-methylxanthine and iridocyclitis. Leave-one-out analysis: used to assess whether any single instrumental variable drove the causal effect. Scatterplot: all 5 methods are described in this paper. Light blue, dark blue, light green, dark green, and pink lines represent inverse variance weighted (IVW), MR-Egger, simple mode, weighted median (WM), and weighted mode, respectively. MR Mendelian randomization, SNP single nucleotide polymorphism.
