Figure 4
Hypoxia gene formula-based prediction models of the human islet transplantation outcomes in mice (A) The flowchart (top panel) outlines the formula-based outcome predictions for 85 islet batches using 11 key hypoxia-related genes. Two representative applications are shown based on "Estimated AUC_0–28" values: Application #1 predicts post-transplantation outcomes for two groups, and Application #2. predicts outcomes for four detailed groups. Bottom panels illustrate detailed information including cutoffs of AUC_0–28, predicted outcomes, and # of mice. (B) Two-group outcome prediction with a cutoff at 7000 mg/dl*days. (C) Four-group outcome prediction with multiple cutoffs. Average blood glucose data of mice are plotted in each group. Smoothers using the spline method (lambda = 2) with the confidence of fit are shown.
