Table 2 Demographic features of diagnostic and biomarkers groups.

	SCD AP−	SCD AP+	MCI AP−	MCI AP+	AD-d
	N° 20	N° 8	N° 24	N° 17	N° 21
Age at onset in years	*55.60 (± 9.69)°**	62.50 (± 10.9 9)	60.13 (± 11.45)^	*70.31 (± 5.26)^**	64.76 (± 5.38)°
Age at plasma collection	62.83 (± 8.33)^+#	73.63 (± 6.05)⁺	67.92 (± 8.71)	74.06(± 5.54)	69.26 (± 5.45)^#
Disease duration	5.15 (± 6.18)	10.25 (± 6.34)^&@	5.65 (± 6.77)	3.33 (± 3.16)^&	2.57 (± 3.46)^@
Family history of AD	85.00%^§	75.00%	58.33%	64.70%	52.38%^§
Sex (M–F)	4–16	4–4	8–16	7–10	10–11
Years of education	13.05 (± 3.32)	12.63 (± 5.09)	11.46 (± 4.55)	13.88 (± 3.87)	10.47 (± 5.34)
MMSE	28.03 (± 1.56)^ç	27.63 (± 2.10)^£	26.18 (± 2.03)^$	25.48 (± 2.18)^€	20.70 (± 5.02)^ç,£,$,€
APOE ɛ4+	35.00%^α	37.50%	16.66%^β,γ	76.47%^β	61.90%^α,γ
Impaired renal function	0	0	1 (4.16%)	0	0
Log p-tau181 (pg/ml)	0.23 (± 0.16)^a,b,c	0.44 (± 0.08)^a,d	0.22 (± 0.26)^d,e,f	0.57 (± 0.13)^b,e	0.59 (± 0.14)^c,f
Log NfL (pg/ml)	1.07 (± 0.12)^g,h,i	1.33 (± 0.18)^g,l	1.11 (± 0.17)^l,m,n	1.32 (± 0.20)^h,m	1.29 (± 0.12)^i,n

Values are reported as mean and standard deviation or frequencies or percentages for continuous variables and categorical variables respectively. Statistically significantly different values between the groups are reported as bold.
M males, F females, MMSE mini mental state examination.
Statistically significance: p < 0.05, *p < 0.001, Cohen’s d = 1.887; °p = 0.014, Cohen’s d = 1.043; ^p = 0.006, Cohen’s d = 1.143; ⁺p = 0.006, Cohen’s d = 1.484; ^#p < 0.001, Cohen’s d = 0.913; ^&p = 0.037, Cohen’s d = 1.381; ^@p = 0.010, Cohen’s d = 1.504; ^§χ² 5.03, p = 0.043, Cramer’s V 0.350; ^çp < 0.001, Cohen’s d = 1.974; ^£p < 0.001, Cohen’s d = 1.801; ^$p < 0.001, Cohen’s d = 1.431; ^€p < 0.001, Cohen’s d = 1.235; ^αχ² 6.36, p = 0.020, Cramer’s V 0.269; ^βχ² 14.66, p < 0.001, Cramer’s V 0.598; ^γχ² 9.75, p = 0.002, Cramer’s V 0.465; ^ap = 0.002, Cohen’s d = 1.629; ^bp < 0.001, Cohen’s d = 2.332; ^cp < 0.001, Cohen’s d = 2.395; ^dp = 0.048, Cohen’s d = 1.144; ^ep < 0.001, Cohen’s d = 1.703; ^fp < 0.001, Cohen’s d = 1.772; ^gp = 0.003, Cohen’s d = 1.700; ^hp < 0.001, Cohen’s d = 1.516; ⁱp = 0.001, Cohen’s d = 1.167; ^lp = 0.014, Cohen’s d = 1.257; ^mp = 0.001, Cohen’s d = 1.131; ⁿp = 0.004, Cohen’s d = 1.223.

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