Table 3 Diagnostic accuracy of p-tau181, NfL and the combined model NfL + p-tau181 in predicting A, T, N and AP status.

From: Future perspective and clinical applicability of the combined use of plasma phosphorylated tau 181 and neurofilament light chain in Subjective Cognitive Decline and Mild Cognitive Impairment

 

SCD

MCI

SCD + MCI

A

Log p-tau181

0.79 [0.61–0.96]

0.79 [0.61–0.96]

0.81 [0.71–0.92]

Log NfL

0.80 [0.59–1]

0.80 [0.59–1]

0.77 [0.65–0.88]

NfL + p-tau181

0.81 [0.62–1]

0.81 [0.62–1]

0.84 [0.75–0.94]

T

Log p-tau181

0.88 [0.75–1]

0.88 [0.75–1]

0.89 [0.81–0.96]

Log NfL

0.88 [0.70–1]

0.88 [0.70–1]

0.82 [0.72–0.93]

NfL + p-tau181

0.92 [0.81–1]

0.92 [0.81–1]

0.92 [0.86–0.98]

N

Log p-tau181

0.68 [0.48–0.89]

0.68 [0.48–0.89]

0.81 [0.71–0.91]

Log NfL

0.69 [0.48–0.89]

0.69 [0.48–0.90]

0.74 [0.62–0.86]

NfL + p-tau181

0.68 [0.48–0.89]

0.68 [0.48–0.89]

0.80 [0.70–0.90]

AP status

Log p-tau181

0.88 [0.68–1]

0.88 [0.76–1]

0.89 [0.81–0.96]

Log NfL

0.88 [0.76–1]

0.88 [0.65–1]

0.81 [0.70–0.93]

NfL + p-tau181

0.93 [0.80–1]

0.93 [0.80–1]

0.92 [0.86–0.99]

  1. Values quoted in table are accuracy (in percentages %) and C.I., between brackets.
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