Table 2 Levels of Glutathion (GSH) (nmol g−1) in brain of rats treated with Nulanza in combination with Cytarabine or Etoposide.

From: Intake of oligoelements with cytarabine or etoposide alters dopamine levels and oxidative damage in rat brain

GSH (nmol g−1)

Treatment

Cortex

Striatum

Cerebellum-medulla oblongata

Control

64.50 ± 8.81

80.11 ± 7.44

60.50 ± 17.33

Nulanza

48.52 ± 20.12

66.48 ± 24.75

45.54 ± 14.88

Cytarabine

92.87 ± 6.50*

53.43 ± 12.09*

62.97 ± 12.72

Etoposide

57.91 ± 20.44

68.55 ± 16.73

51.99 ± 7.71

Nulanza + Cytarabine

44.40 ± 15.45

63.11 ± 13.02

44.83 ± 5.30

Nulanza + Etoposide

32.09 ± 8.20**

55.98 ± 23.79

51.48 ± 7.34

  1. Animals treated with cytarabine showed increased GSH levels in cortex: Anova *p < 0.05**p < 0.003, while a decrease was observed for OE + etoposide group ***p < 0.006 versus etoposide. Reduction in GSH in striatum was observed for cytarabine treated group *p < 0.05. No significant differences were found in cerebellum/medulla-oblongata.
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