Figure 2 | Scientific Reports

Figure 2

From: Chemogenetic inhibition of the lateral hypothalamus effectively reduces food intake in rats in a translational proof-of-concept study

Figure 2

Effect of s.c. applied CNO stimulation on the food intake of LH-hM4D(Gi) rats. (A) Effect of CNO on SHAM-operated control rats; (B) Effect of CNO on AAV5 LH-hM4D(Gi) rats; (C) Effect of CNO on AAV9 LH-hM4D(Gi) rats. Post-hoc Tukey HSD tests: * p < 0.05, ** p < 0.01, *** p < 0.001, compared to the vehicle-treated group; #  p < 0.05, compared to the CNO 100 µg/kg group.

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