Figure 4 | Scientific Reports

Figure 4

From: Effects of a high-fat diet on cognition and brain distribution of intranasal insulin in E3 and E4 male and female mice

Figure 4

Weight gain over study period for INL insulin distribution. Weights were recorded each month. Both (A) female and (B) male mice gained weight on a HFD (ANOVA). The total weight gained after 6 months, as expressed as a percent of the baseline, was statistically significant for (C) females and (D) males and there were significant differences due to apoE genotype for both sexes (ANOVA). Tukey post hoc: *p < 0.05 as marked. LFD: low-fat diet, HFD: high-fat diet. Females: n = 14 E3 LFD, n = 15 E3 HFD, n = 17 E4 LFD, n = 16 E4 HFD; Males: n = 11 E3 LFD, n = 4 E3 HFD, n = 16 E4 LFD, n = 10 E4 HFD.

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