Figure 5
125I-insulin distribution after IN delivery over time in E3 and E4 mice. The %Inj/g average for (A) whole brain, (B) olfactory bulb, (C) cortex, (D) hypothalamus, and (E) hippocampus or (F) %Ing/ml average for serum at each time point in E3 mice is presented. The %Inj/g average for (G) whole brain, (H) olfactory bulb, (I) cortex, (J) hypothalamus, and (K) hippocampus or (L) %Ing/ml average for serum at each time point in E4 mice is presented. Two-way ANOVA showed significant change over time for all regions except cortex. n = 3–9/timepoint/group (see Table 2 for n per group and timepoint). %Inj/g: percent injected insulin per gram of tissue.
