Figure 6 | Scientific Reports

Figure 6

From: PPARγ regulates osteoarthritis chondrocytes apoptosis through caspase-3 dependent mitochondrial pathway

Figure 6

Schematic depiction of the mechanisms of PPARγ regulates OA chondrocytes apoptosis through caspase-3 dependent mitochondrial pathway (By Figdraw). PPARγ regulates oxidative stress induced OA chondrocytes apoptosis by down-regulation of iNOS and reducing NO production, which results in the inhibition of ROS production, thereby maintaining the stability of MMP and preventing cytochrome C overflow, finally blocking the activation of caspase-9 and caspase-3.

Back to article page