Table 5 Stability prediction of six most significant mutant proteins using DynaMut2.

From: In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene

SL

Variant

ΔΔG (kcal/mol)

Stability

Wild Type

Mutant

01

I123S

− 2.39

Destabilising

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02

R207C

− 0.69

Destabilising

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03

V456M

− 0.67

Destabilising

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04

D463G

− 0.31

Destabilising

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05

R602H

− 1.13

Destabilising

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06

R633W

− 1.6

Destabilising

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