Figure 3

ABR threshold shift of three groups at three time points. The ABRs were measured at 8, 16, and 32 kHz. The experimental groups included no pump control (dummy electrode insertion only), control with pumps (dummy electrode and 1004 or 2004 pumps filled with PBS), and two groups of SL treatment (SL-1004: low-capacity pump; SL-2004: high-capacity pump). The threshold shifts were compared to the baseline value (preABR) and averaged. (A) At 1 day after dummy electrode insertion, the difference in threshold shifts at all frequencies among the groups was evaluated. Significant differences in the shift between the control and SL-2004 groups compared to control were found at 16 or 32 kHz. (B) At 7 days after dummy electrode insertion, differences among groups were found at all frequencies. At 16 and 32 kHz, significant differences were observed between the 2004c and SL-2004 groups. (C) At 30 days after dummy electrode insertion, a difference in threshold shift among the groups was found at all frequencies. At all frequencies, both control with pump groups (1004c and 2004c) showed a significantly higher threshold shift compared to the two SL groups. SL-2004 group showed statistically smaller threshold shift compared to control at all frequencies. *p < 0.05, **p < 0.01, and ***p < 0.001.