Table 2 Main Results of the MR analyses PBC on EHAIDs.

From: Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization

Outcome

nSNPs

r2

F

Inverse variance weighted

MR Egger

Weighted median

Weighted mode

Steiger directionality

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

Correct causal direction

P-value

RA

19

6.69%

92.38

1.20 (1.16–1.24)

8.40E−28

1.16(1.04–1.29)

1.88E−02

1.19(1.13–1.25)

1.44E−11

1.19 1.12–1.27)

4.29E−05

TRUE

1.65E−172

SLE

21

8.34%

106.15

1.41 (1.33–1.49)

2.71E−32

1.37 (1.13–1.66)

5.05E−03

1.42 (1.31–1.54)

8.04E−17

1.43 (1.28–1.60)

4.33E−06

TRUE

1.50E−71

SS

11

3.38%

77.91

1.28 (1.04–1.57)

1.77E−02

1.10 (0.40–3.02)

8.58E−01

1.27 (0.96–1.69)

9.65E−02

1.30 (0.86–1.96)

2.47E−01

TRUE

2.67E−06

SSc

19

7.65%

106.82

1.44 (1.35–1.53)

1.19E−29

1.54 (1.22–1.93)

1.78E−03

1.49 (1.35–1.64)

3.68E−15

1.52 (1.34–1.72)

3.49E−06

TRUE

1.47E−121

AITD

22

8.17%

99.07

1.14 (1.12–1.16)

1.79E−45

1.11 (1.05–1.18)

1.55E−03

1.13 (1.10–1.16)

3.44E−17

1.12 (1.08–1.16)

1.79E−06

TRUE

0.00E+00

AHYPER

29

11.20%

106.42

1.19 (1.12–1.26)

1.13E−08

1.13 (0.93–1.38)

2.26E−01

1.16 (1.07–1.27)

5.47E−04

1.16 (1.02–1.32)

3.25E−02

TRUE

0.00E+00

GD

30

11.38%

104.81

1.11 (1.06–1.16)

2.70E−05

1.04 (0.88–1.23)

6.27E−01

1.09 (1.02–1.17)

7.84E−03

1.07 (0.97–1.19)

1.85E−01

TRUE

0.00E+00

AHYPO

19

7.42%

103.36

1.10 (1.08–1.12)

9.12E−27

1.10 (1.04–1.17)

7.02E−03

1.09 (1.06–1.12)

3.46E−10

1.09 (1.05–1.13)

2.83E−04

TRUE

0.00E+00

IBD

9

3.25%

91.46

1.11 (1.08–1.15)

3.64E−11

1.12 (0.96–1.31)

1.88E−01

1.13 (1.08–1.18)

1.82E−07

1.14 (1.06–1.21)

5.45E−03

TRUE

3.33E−92

CD

11

4.33%

100.69

1.01 (0.98–1.05)

4.08E−01

1.05 (0.92–1.20)

5.07E−01

1.03 (0.98–1.08)

2.59E−01

1.02 (0.96–1.08)

6.31E−01

TRUE

2.97E−138

UC

8

3.05%

96.35

1.10 (1.05–1.14)

1.58E−05

1.19 (1.01–1.41)

8.32E−02

1.08 (1.02–1.15)

5.90E−03

1.11 (1.02–1.20)

5.09E−02

TRUE

7.59E−83

CeD

10

4.53%

116.26

0.97 (0.92–1.02)

2.00E−01

0.94 (0.75–1.17)

5.78E−01

0.97 (0.91–1.04)

3.59E−01

0.97 (0.90–1.05)

4.49E−01

TRUE

6.29E−59

MS

20

6.59%

86.39

1.27 (1.23–1.32)

5.08E−36

1.31 (1.14–1.50)

1.10E−03

1.22 (1.15–1.30)

1.07E−10

1.21 (1.09–1.33)

1.32E−03

TRUE

7.21E−220

PoS

23

7.85%

90.64

1.06 (1.02–1.09)

1.25E−03

1.15 (1.04–1.28)

1.63E−02

1.08 (1.03–1.14)

2.66E−03

1.08 (1.01–1.16)

3.07E−02

TRUE

2.03E−228

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