Table 3 Main results of the MR analyses EHAIDs on PBC.

From: Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization

Exposure

nSNPs

r2

F

Inverse variance weighted

MR Egger

Weighted median

Weighted mode

Steiger directionality

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

Correct causal direction

P-value

RA

19

2.98%

92.45

1.16 (1.08–1.26)

1.28E−04

1.23 (1.03–1.46)

3.47E−02

1.18 (1.06–1.32)

2.14E−03

1.19 (1.07–1.33)

4.86E−03

TRUE

1.38E−67

SLE

12

4.24%

52.59

1.32 (1.24–1.40)

3.93E−19

1.23 (0.99–1.52)

9.38E−02

1.37 (1.26–1.48)

2.52E−13

1.39 (1.24–1.56)

1.47E−04

TRUE

7.05E−44

SS#

1

1.96%

42.62

1.82 (1.65–2.01)

3.64E−33

      

TRUE

4.35E−03

SSc

2

0.27%

36.26

1.55 (1.24–1.94)

1.20E−04

      

TRUE

1.86E−03

AITD

30

0.31%

78.22

1.04 (0.96–1.12)

3.68E−01

1.19 (0.96–1.49)

1.26E−01

1.02 (0.90–1.14)

7.87E-01

1.01 (0.90–1.14)

8.51E−01

TRUE

1.57E−04

AHYPER

2

0.04%

56.35

0.99 (0.87–1.11)

8.10E−01

      

TRUE

8.30E−03

GD

2

0.05%

87.77

0.94 (0.82–1.08)

4.18E−01

      

TRUE

1.35E−02

AHYPO

45

1.48%

105.37

1.10 (1.02–1.20)

1.98E−02

1.31 (1.07–1.60)

1.21E−02

1.09 (0.94–1.27)

2.37E−01

1.11 (0.94–1.32)

2.22E−01

TRUE

3.46E−27

IBD

54

7.31%

95.78

1.14 (1.07–1.21)

3.16E−05

1.11 (0.91–1.35)

3.23E−01

1.09 (0.99–1.20)

8.79E−02

1.07 (0.94–1.22)

2.95E−01

TRUE

4.68E−185

CD

56

10.73%

111.27

1.13 (1.08–1.18)

5.67E−07

1.11 (0.97–1.27)

1.22E−01

1.10 (1.02–1.19)

1.06E−02

1.11 (1.02–1.20)

2.00E−02

TRUE

1.25E−279

UC

35

5.01%

71.84

1.08 (1.01–1.16)

2.64E−02

1.00 (0.80–1.25)

9.78E−01

1.08 (0.97–1.20)

1.89E−01

1.08 (0.93–1.25)

3.22E−01

TRUE

5.15E−120

CeD

11

5.08%

58.58

1.21 (1.11–1.33)

3.94E−05

1.74 (0.98–3.10)

9.28E−02

1.25 (1.10–1.43)

8.95E−04

1.32 (1.07–1.63)

2.61E−02

TRUE

8.10E−67

MS

23

0.94%

47.85

1.03 (0.97–1.11)

3.31E−01

1.02 (0.75–1.38)

9.24E−01

1.05 (0.94–1.17)

4.01E−01

1.02 (0.91–1.16)

7.16E−01

TRUE

7.12E−19

PoS

21

2.56%

55.18

1.06 (0.98–1.15)

1.51E−01

1.19 (0.86–1.65)

3.18E−01

1.09 (0.97–1.22)

1.55E−01

1.13 (0.94–1.35)

1.97E−01

TRUE

2.59E−55

Back to article page