Table 6 In silico predicted properties related to drug-likeness (oral bioavailability) and ADMET (absorption, distribution, metabolism, excretion, and toxicity) profile of the promising compounds 7g and 7k.

Class	Properties	7g	7k
Drug-likeness (physicochemical properties related to oral bioavailability)	MW	276.130	243.16
	LogP	3.299	4.114
	HBA	3	2
	HBD	2	1
	RotB	5	5
	TPSA	44.89	29.1
	Num. Viol	0	0
	LogS	− 4.233	− 4.647
Absorption	GI abs	High	High
Absorption	P-gp inhib/subs	Yes/No	Yes/No
Distribution	BBB perm	Yes	Yes
Metabolism	CYP1A2	Inhibitor	Inhibitor
	CYPC19	Inhibitor	Inhibitor
	CYP2C9	No	No
	CYP2D6	Inhibitor	No
	CYP3A4	Inhibitor	No
Excretion	t½	Short	Short
Toxicity	Mutagenic	No	No
	Tumorogenic	No	No
	Irritant	No	No
	Reproductive	No	No
	Hepatotoxicity	No	No
	hERG blockers	No	No

MW = molecular weight (g mol⁻¹); LogP = Log (base 10) of the partition coefficient (P) of a solute between 1-octanol and water at pH = 7; HBA = number of H-bond acceptors (sum of N + O); HBD = number of H-bond donors (sum of NH + OH); RotB = number of rotatable bonds; TPSA = topological polar surface area (Å²); Num. Viol. = number of violations of the rules of Lipinski and Veber; LogS = Log (base 10) of the solubility (S) of a solute in water (mol L⁻¹); GI abs = Gastrointestinal absorption; BBB perm. = Blood–brain barrier permeability; P-gp inhib/subs = P-glycoprotein (efflux pump) inhibitor or substrate; CYP (1A2, C19, 2C9, 2D6, 3A4) = activity on cytochrome P-450 (CYP) enzymes; t½ = half-life; Reproductive = Reproductive effect.

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