Figure 5
Heatmap of Spearman’s correlation coefficients for continuous clinical and laboratory characteristics or Mann–Whitney U test effect sizes for dichotomous characteristics in comparison to baseline plasma levels of IL-2R, HGF, TNF-RII, SDF-1α, CD30, MIF, IL-16, APRIL, SCF, MIP-1β, and IL-4. Data are depicted in colours ranging from blue to red, indicating a negative to positive effect size R or Spearman’s ρ grouped by k-means clustering. Samples from all 215 study participants (AIS and sCeAD-nonAIS) at baseline were included in this figure. The heatmap was created by the authors using GraphPad Prism-10 (GraphPad Software Inc., La Jolla, California, United States; https://www.graphpad.com). APRIL a proliferation-inducing ligand, AT-III antithrombin-III, CCA/ICA common carotid artery/internal carotid artery, CD30 TNF receptor superfamily member 8, CE cardioembolic stroke, CRP C-reactive protein, HbA1c glycated haemoglobin A1c, HDL-C high-density lipoprotein cholesterol, HGF hepatocyte-growth-factor, IL interleukin, IL-2R interleukin 2 receptor, INR international normalised ratio, LAA large artery atherosclerotic stroke, LDL-C low-density lipoprotein cholesterol, MIF macrophage migration inhibitory factor, MIP-1β macrophage inflammatory protein-1β, mRS modified Rankin Scale, NIHSS National Institutes of Health Stroke Scale, PT prothrombin time, sCeAD spontaneous cervical artery dissection, SCF stem cell factor, SDF-1α stromal-cell-derived factor-1α, SVO small vessel occlusive stroke, TIA transient ischaemic attack, TNF-RII tumour necrosis factor receptor 2.
