Figure 4 | Scientific Reports

Figure 4

From: Bioinformatics analysis and experimental verification of the cancer-promoting effect of DHODH in clear cell renal cell carcinoma

Figure 4

Correlation analysis between immune cell infiltration and DHODH in ccRCC. (A) Differences in the infiltration scores of the following 24 immune cell types, activated DC cells (aDC), B cells, CD8 T cells, cytotoxic cells, DC cells, eosinophils, immature DC cells (iDC), macrophages, mast cells, neutrophils, NK CD56bright cells, NK CD56dim cells, NK cells, plasmacytoid DC cells (pDC), T cells, T helper cells, T central memory (Tcm), T effector memory cells (Tem), T follicular helper cells (Tfh), T gamma delta cells (Tgd), Th1 cells, Th17 cells, Th2 cells, and Treg cells between high and low DHODH expression groups. (B) Lollipop plots showing the correlation between infiltration scores of 24 immune cell types and DHODH gene expression in patients with ccRCC from TCGA database. (C) Chord diagram displaying the correlation between the expression of DHODH and that of six common immune cell types. (D) DHODH expression profile in different single cells across multiple GEO datasets. (E) Circular dendrogram demonstrating the correlation between DHODH and infiltration of 115 different subtypes of tumor-infiltrating immune cells.

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