Figure 4 | Scientific Reports

Figure 4

From: Identification of 8 candidate microsatellite instability loci in colorectal cancer and validation of the ACVR2A mechanism in the tumor progression

Figure 4

ACVR2A suppression enhances the expression of PI3K/AKT/mTOR signaling pathway-related proteins under hypoxic conditions. (A) Western blot analysis of NOX4, phospho-PI3K (p-PI3K), phospho-mTOR (p-mTOR), MMP3, MMP9, Cyclin A, Cyclin D1, HIF1α, and VEGF protein levels; (B) Quantification of relative protein expression levels of NOX4, p-PI3K, p-mTOR, MMP3, MMP9, Cyclin A, Cyclin D1, HIF1α, and VEGF.

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