Figure 5 | Scientific Reports

Figure 5

From: Identification of a functional missense variant in the matrix metallopeptidase 10 (MMP10) gene in two families with premature myocardial infarction

Figure 5

MMP10 overexpression, knockdown, protein expression, gene Co-expression, and CXCL1/CXCL8 expression. (a) Left: MMP10 overexpression with quantitative RT-qPCR, expressed as fold-change induction. Middle: MMP10 knockdown with siRNA expressed as fold-change. Right: Quantification of MMP10 protein expression, indicating its concentration; EV = empty vector, (b) Gene co-expression of MMP10 (center) with a description of the top 10 most correlated genes (correlation > 0.643 and mutual correlation ≥ 0.601). (c) Quantitative determination of CXCL1 and CXCL8 concentrations using ELISA; All data: n = 9, U-test, violin plots, Mdn (IQR), n.s. = not significant, * = p < 0.05, ** = p < 0.01, *** = p < 0.001.

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