Figure 2 | Scientific Reports

Figure 2

From: Proteomic analysis of pleomorphic dermal sarcoma reveals a fibroblastic cell of origin and distinct immune evasion mechanisms

Figure 2

Upregulation of the PI3K/AKT signaling pathway in PDS by a PDGFRB-PDGFD axis. (a) Alluvial diagram of corresponding R/L interactions for malignant melanoma (MM), pleomorphic dermal sarcoma (PDS) and cutaneous squamous cell skin cancer (cSCC). The y-axis corresponds to the number of contributing genes to each enriched Reactome pathway52. For readability, we have abbreviated R/L interactions, a full list can be found in Table S3. (b) Scatter plots of Spearmen correlation for PDGFRB and PDGFD for each entity separately. (c) Boxplot for comparison of PDGFD abundance for MM (n = 27), PDS (n = 24) and cSCC (n = 20) using a compared using a Wilcoxon Rank Sum Test.

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