Figure 1
From: Expression and potential molecular mechanism of TOP2A in metastasis of non-small cell lung cancer
Expression of TOP2A in NSCLC. (A) TOP2A was highly expressed in LUAD and LUSC [red bars:tumor tissue; blue bars:normal tissue]. (B) TOP2A expression level was higher in NSCLC [Source: TCGA (n = 1037) database]. (C) TOP2A expression was notably elevated in NSCLC tissue than in paired normal tissue [Sources: TCGA (n = 108), GSE19804 (n = 60)]. (D) Bioinformatics study and validation of clinical specimens revealed that patients with elevated TOP2A levels had a poor prognosis. (E) TCGA (n = 1037) data revealed an association between NSCLC and TOP2A expression. (F) The levels of TOP2A protein were considerably elevated in NSCLC cells compared to BEAS-2B cells. (G) Immunohistochemical analysis demonstrated that TOP2A protein expression was considerably greater in lung cancer tissue than in normal lung tissue (200×). *P < 0.05, **P < 0.01, ***P < 0.001 or ****P < 0.0001. All experiments were repeated three times independently.
