Figure 1

Intrinsic tumour proliferation, apoptosis and necrosis in BC-PDEs. (A) % labelling index for Ki67 (proliferation), cPARP (apoptosis) and % necrosis areas in untreated PDEs was derived from 55 patient samples. A single dot represents the median value of respective values for all PDEs derived from a given patient sample. (B) Intrinsic levels of tumour proliferation (left), apoptosis (middle) and necrosis (right) in tumour samples from patients with ( +) and without (-) neo-adjuvant therapy. (C) Intrinsic levels of tumour proliferation (left), apoptosis (middle) and necrosis (right) according to tumour grade. (D) Intrinsic levels of tumour proliferation (left), apoptosis (middle) and necrosis (right) according to tumour stage. (E) Intrinsic levels of tumour proliferation (left), apoptosis (middle) and necrosis (right) according to tumour histology. (F) Intrinsic levels of tumour proliferation (left), apoptosis (middle) and necrosis (right) according to tumour molecular subtype. Statistics were performed using the Mann–Whitney test, where p < 0.05 is indicated by *, P < 0.01 is indicated by ** and p < 0.001 is indicated by ***. Values displayed above each group represent the number of patient samples in each group.