Figure 1 | Scientific Reports

Figure 1

From: STEAP2 promotes hepatocellular carcinoma progression via increased copper levels and stress-activated MAP kinase activity

Figure 1

STEAP2 and Copper Levels are Elevated in HCC Tumor Tissue. (a) Heatmap showing unsupervised clustering of differentially expressed genes (1,288 genes with EdgeR Analysis) for 9 HCC tumor (T) and adjacent normal (N) samples from Hispanic/Latino patients. (b) DAVID Analysis with GO terms selected from top 20 biological process and molecular functions. Grey bars: GO terms that includes STEAP2. (c) STEAP2 mRNA levels increased in HCC tumor (T) tissue compared to paired non-tumor (N) tissue from Hispanic/Latino patients measured by real time RT-PCR. Tumor STEAP2 mRNA level was normalized by its paired adjacent non-tumor tissue STEAP2 mRNA level and is expressed as relative expression. (d) STEAP2 protein levels in paired HCC tumor (T) and adjacent non-tumor tissue (N) in Hispanic/Latino patients measured by Western blot. Western blot image was cropped to show STEAP2 protein band. E. Copper levels were measured in 10 paired samples via ICP-MS. *P < 0.05; **P < 0.01; ***P < 0.001. ****P < 0.0001 with unpaired T-test (c) or Wilcoxon test (e).

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