Figure 2
From: Cell adhesion molecule CD44 is dispensable for reactive astrocyte activation during prion disease
Response to CNS prion disease is unaltered in CD44-deficient mice. (A) CatWalk gait analysis weekly assessment of average speed and (B) front base of stance (BOS) of naïve vs prion infected WT mice. (C) CatWalk gait analysis average speed and (D) front BOS of naïve vs prion infected CD44−/− mice. Points represent group mean and error bars 95% confidence interval. Two-Way ANOVA with Tukey’s multiple comparison test. *P < 0.05; **P < 0.005; ***P < 0.001. N = 6–10 mice/group. (E) Survival curve analysis of WT and CD44−/− mice following intracerebral prion infection, Log-rank Mantel Cox Test. N = 6 mice/group. (F) Representative images from hematoxylin and eosin-stained hippocampus CA1 of naïve, 140 dpi or terminal prion infected WT and CD44−/− mice. Scale bar = 100 µm. (G) Lesion profile analysis of 140 dpi prion-infected brains. Points represent the mean vacuolation score, error bars = ± SEM. Two-way ANOVA, Sidak's multiple comparisons test, N = 4 mice/group. (H) Lesion profile analysis of terminal prion-infected brains. Points represent the mean vacuolation score, error bars = ± SEM. Two-way ANOVA, Sidak's multiple comparisons test, N = 6 mice/group.
