Figure 5 | Scientific Reports

Figure 5

From: Stress–strain curve and elastic behavior of the fibrotic lung with usual interstitial pneumonia pattern during protective mechanical ventilation

Figure 5

Simplified diagram illustrating the strain threshold predisposing to VILI for EUIP and ARDS. For these latter the risk of VILI starts increasing at 1.5 and becomes significant above 25,45, resulting in lung inflammation and alveolar rupture. Our data show that in patients with UIP-lung the harmful strain threshold starts for strain value of 0.35 and could be reached slightly above 0.5. EUIP, Acute exacerbation of interstitial lung disease with usual interstitial pneumonia pattern; ARDS, Acute respiratory distress syndrome.

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