Table 1 Blood gas analyses and respiratory mechanics of the EUIP and the ARDS population at different PEEP levels
Variable | EUIP | ARDS | p-value |
|---|---|---|---|
ZEEP phase | |||
EL, cmH2O/L | 43.2 (39.9–54.4) | 21 (17.3–35.6) | 0.01 |
Ecw, cmH2O/L | 3.3 (2.8–7) | 4.5 (4–6.3) | 0.72 |
Etot, cmH2O/L | 50 (43.8–57.4) | 26.4 (21.6–41.2) | 0.01 |
PL,EI, cmH2O | 16.1 (13.3–18.5) | 7 (4.9–7) | 0.0002 |
PL,EE, cmH2O | − 4.3 (− 7.7-− 2.9) | − 4 (− 7.5-− 1.2) | 0.71 |
ΔPaw, cmH2O | 17.5 (16.3–19.3) | 21.2 (17.5–22.8) | 0.13 |
ΔPL, cmH2O | 21.3 (18.1–23.8) | 9.4 (8.9–13.2) | 0.0003 |
EELV, ml | 693 (588–717) | 820 (599–1047) | 0.18 |
Vt/PBW, ml/kg | 4.9 (3.9–5.6) | 5.1 (4.6–5.4) | 0.67 |
Vt, ml | 360 (315–414) | 408 (396–426) | 0.09 |
Strain, ratio | 0.58 (0.49–0.62) | 0.5 (0.39–0.67) | 0.68 |
pH, value | 7.42 (7.39–7.44) | 7.39 (7.37–7.41) | 0.17 |
pO2, cmH2O | 75 (72–80) | 80 (65–90) | 0.73 |
pCO2, cmH2O | 38 (35–41) | 39 (38–42) | 0.35 |
PEEPLOW phase | |||
EL, cmH2O/L | 44 (38.8–57.8) | 18.3 (15.4–29.5) | 0.003 |
Ecw, cmH2O/L | 3.6 (2.7–7) | 4.3 (4–6.4) | 0.73 |
Etot, cmH2O/L | 52 (42.3–60.9) | 23.6 (19.5–35.3) | 0.005 |
PL,EI, cmH2O | 14 (10.9–18.8) | 12 (8.7–15) | 0.26 |
PL,EE, cmH2O | − 2.2 (− 6.5-− 1) | − 2.1 (− 5.4-− 0.6) | 0.78 |
ΔPaw, cmH2O | 18.2 (14.8–18.8) | 20.8 (16.2–26) | 0.18 |
ΔPL, cmH2O | 18.4 (15.6–21.8) | 16.1 (9.3–19.4) | 0.32 |
PEEP, cmH2O | 4 (4–4) | 4 (4–5) | 0.71 |
EELV, ml | 702 (625–762) | 1010 (733–1175) | 0.04 |
Vt/PBW, ml/kg | 5.3 (4.4–6.1) | 5.8 (5.4–6.4) | 0.27 |
Vt, ml | 401 (354–442) | 476 (471–499) | 0.01 |
Strain, ratio | 0.62 (0.6–0.74) | 0.96 (0.63–1.1) | 0.08 |
pH, value | 7.4 (7.38–7.43) | 7.39 (7.35–7.4) | 0.18 |
pO2, cmH2O | 75 (72–78.5) | 80 (69.5–95.5) | 0.31 |
pCO2, cmH2O | 39 (36–42.5) | 40 (38.5–44) | 0.39 |
PEEPTITRATED phase | |||
EL, cmH2O/L | 50 (42.8–60.5) | 15.4 (14.4–20.9) | < 0.0001 |
Ecw, cmH2O/L | 3.9 (3.4–7.2) | 4.3 (4–6.5) | 0.97 |
Etot, cmH2O/L | 59 (47.3–64.2) | 21 (18.6–26.6) | < 0.0001 |
PL,EI, cmH2O | 26.2 (19.9–29.8) | 18.2 (16.5–20.3) | 0.03 |
PL,EE, cmH2O | 0.3 (0.3–1.4) | 0.6 (0.1–1) | 0.63 |
ΔPaw, cmH2O | 20 (17.3–21.8) | 16.5 (14–18.4) | 0.06 |
ΔPL, cmH2O | 25 (19–29.5) | 17.6 (15.6–20.2) | 0.04 |
PEEP, cmH2O | 12 (10–14) | 14 (12–17.5) | 0.03 |
EELV, ml | 714 (635–755) | 1260 (912–1575) | 0.01 |
Vt/PBW, ml/kg | 5.6 (4.9–6.7) | 6.5 (6.3–6.7) | 0.12 |
Vt, ml | 438 (388–486) | 540 (505–599) | 0.01 |
Strain, ratio | 0.69 (0.63–0.83) | 1.8 (1.5–1.9) | < 0.0001 |
pH, value | 7.39 (7.36–7.42) | 7.36 (7.32–7.39) | 0.14 |
pO2, cmH2O | 78 (55–85) | 80 (73–91) | 0.3 |
pCO2, cmH2O | 40 (37–44) | 42 (40–48) | 0.27 |
