Figure 4

UMAP of SCT expression in mature and progenitor EECs. Top-left: Cell distribution by intestinal region with Jejunum (blue), Middle Ileum (orange), Proximal Ileum (green), Terminal Ileum (red). Top-middle: CHGA gene expression levels across cells, color-coded from low (purple) to high (yellow). Top-right: SCT gene expression with a similar color gradient. Bottom-left: Leiden clustering of cells based on SCT expression, distinguishing low SCT (orange) as progenitor EECs and high SCT (blue) as mature EECs. Bottom-middle and bottom-right: NEUROG3 and SOX4 gene expression, respectively.