Table 1 Clinical and hormonal characteristics of T1DM women with and without PCOS, with positive and negative TPOAb.

From: The association of thyroid autoimmunity with ovarian reserve in women with type 1 diabetes with and without polycystic ovary syndrome

 

PCOS + TPOAb, N = 12

PCOS + noTPOAb, N = 29

noPCOS + TPOAb, N = 18

noPCOS + noTPOAb, N = 24

P-value

Age, years

24 (22–25)

25 (22–29)

27 (25–33)

27 (21–32)

0.213

BMI, kg/m2

25 (21.7–26.1)

25 (22.1–26.3)

24.3 (22.8–27.1)

22.9 (21.125.1)

0.416

T1DM duration, years

12 (5.5–13.5)

10 (8–14)

14 (7–19)

9 (5–13)

0.399

Age of menarche, years

12 (11–13)2

13 (12–14)

14 (13–15)

13 (12–14)

0.009

Total daily insulin dose, U/kg

0.42 (0.4–0.6)

0.5 (0.5–0.6)

0.6 (0.6–0.7)

0.6 (0.5–0.6)

0.059

HbA1c, %

7.1(6.7–7.9)

7.1 (6.6–8.2)4

7.7 (7–8.5)

8.9 (7.3–9.1)

0.014

HbA1c, mmol/mol

54 (50–63)

50 (49–66)

61 (53–69)

74 (56–76)

 

LH, mIU/ml

4.7 (3.9–6.2)

4.5 (3.7–5.6)

4 (2.9–5.4)

4.6 (3.1–5.2)

0.551

FSH, mIU/ml

3.8 (3–4.6)1

5 (3.6–6.4)

4.9 (4.4–6)

6.2 (4.8–7.8)

0.03

LH/FSH

1.3 (0.8–2.6)1

0.9 (0.8–1.4)

0.9 (0.6–1)

0.7 (0.6–0.9)

0.014

Oestradiol, pg/ml

33 (28.8–65.6)2

54 (39.5–85.9)

68.3 (51–91.9)

66.4 (32.6–89.5)

0.06

Testosterone, ng/ml

0.7 (0.6–0.8)

0.7 (0.5–1)

0.5 (0.4–0.7)

0.5 (0.4–0.7)

0.026

FAI

3.8 (2.5–6.4)

3.5 (2.4–5.6)

2.4 (1.6–3.5)

2.5 (1.7–3.3)

0.047

SHBG, nmol/l

67 (54.6–74.9)

68 (47.5–83.5)

61.2 (47.2–91.7)

82.4 (48–98.8)

0.623

Prolactin, ng/ml

9.5 (6.2–12.7)

11.2 (8.3–15.1)

8.2 (6.3–9.4)

9.2 (7.3–13.3)

0.244

AMH, ng/ml

7.1 (4.4–9.3)1

6.4 (4.1–8.9)4

3.9 (2.9–6.8)

2.8 (1.6–4.1)

 < 0.001

O-V, cm3

19 (16.6–27.9)1,2

14.3 (10.7–20.3)

10.2 (9.5–14.1)

10.6 (8.4–15.7)

0.002

O-FN, n

24 (19–29)1

21 (18–28)

15 (13–19)

12 (9–17)

 < 0.001

TSH, IU/ml

2.7 (1.1–3.6)

1.6 (1.3–2.4)3,4

1.3 (1–2.3)

1.6 (0.9–2.5)

0.755

fT4, ng/dl

1.3 (1.2–1.4)

1.2 (1.1–1.3)

1.2 (1.1–1.3)

1.3 (1.2–1.3)

0.494

fT3, pg/ml

3.2 (3–4)

3 (2.7–3.3)

3 (2.7–3.2)

3.2 (2.6–3.4)

0.295

TPOAb, IU/ml

723 (229–1798)1,5

15 (7–26)3

828 (197–1510)6

24 (7–35)

 < 0.001

TV, ml

8.6 (7.2–11)

8.9 (6.9–11.7)

13 (5.9–14.7)

8.2 (6.4–10.7)

0.634

  1. Data are expressed as median (interquartile range).
  2. BMI body mass index, HbA1c haemoglobin A1c, FSH follicle-stimulating hormone, LH luteinizing hormone, FAI free androgen index, SHBG sex hormone binding globulin, TSH thyroid‑stimulating hormone, fT4 free T4, fT3 free T3, AMH anti-Müllerian hormone, O-V ovarian volume, O-FN ovarian follicle number, TV thyroid volume.
  3. 1p < 0.05 PCOS + TPOAb vs noPCOS + noTPOAb.
  4. 2p < 0.05 PCOS + TPOAb vs noPCOS + TPOAb.
  5. 3p < 0.05 PCOS + noTPOAb vs noPCOS + TPOAb.
  6. 4p < 0.05 PCOS + noTPOAb vs noPCOS + noTPOAb.
  7. 5p < 0.05 PCOS + TPOAb vs PCOS + noTPOAb.
  8. 6p < 0.05 noPCOS + TPOAb vs noPCOS + noTPOAb.
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