Figure 1 | Scientific Reports

Figure 1

From: Detection of capillary abnormalities in early diabetic retinopathy using scanning laser ophthalmoscopy and optical coherence tomography combined with adaptive optics

Figure 1

Multi-modal imaging, using the Merlin device, of a diabetes patient (participant no. 5) with moderate NPDR (A–H), compared with a healthy subject (participant no. 18) (I–P). OCT en face large view images (A and I) are overlayed by white rectangles corresponding to the position of the AO-SLO images (B and J, respectively) measuring 4 × 3°. Parafoveal AO-OCT B-scans are overlayed by white rectangles (C–E and K–M, respectively) indicating the segmentation slab of the overlapping AO-OCTA en face images measuring 3 × 3° (F–H and N–P, respectively), corresponding to three capillary plexuses: superficial (F and N), intermediate (G and O) and deep (H and P). AO-OCTA en face images of the intermediate and deep capillary plexuses show that compared to the healthy subject, the capillaries of the patient with diabetes appeared to be wider, more tortuous, with saccular expansions, and more irregularly spaced with larger intercapillary voids, where capillary perfusion appeared to have been lost. Scale bars represent 100 microns. See Fig. 7 for AO-OCT scans overlapping with (G) and (O).

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