Table 1 Baseline characteristics of the women in the CC cotreatment and GnRHa groups before and after matching.

From: The cumulative live birth rate and cost-effectiveness of the clomiphene and gonadotropin cotreatment protocol versus the mid-luteal GnRH agonist protocol in women over 35 years old

Characteristic

Before propensity score matching

After propensity score matching

CC cotreatment group (n = 1,797)

GnRHa group (n = 1,074)

p value

CC cotreatment group (n = 375)

GnRHa group (n = 375)

p value

Maternal age (y)

39 (37, 42)

36 (35, 38)

< 0.001

37 (36, 39)

37 (36, 39)

0.410

Infertility duration (y)

4 (2, 8)

3 (2, 7)

0.023

3 (2, 7)

4 (2, 8)

0.268

Primary infertility, n (%)

381 (21.20)

349 (32, 50)

< 0.001

99 (26.40)

110 (29.33)

0.415

Cycle number, n (%)

< 0.001

 

1

 First cycle

1116 (62.10)

909 (84.64)

279 (74.40)

278 (74.10)

 Repeated cycles

681 (37.90)

165 (15.36)

96 (25.60)

97 (25.90)

Basal FSH level (IU/L)

8.36 (6.77, 10.92)

6.70 (5.68, 7.96)

< 0.001

7.12 (6.01, 9.07)

7.24 (6.13, 8.21)

0.376

Basal LH level (IU/L)

4.51 (3.36, 6.15)

4.75 (3.50, 6.56)

0.001

5.09 (3.47, 6.42)

5.15 (3.65, 6.45)

0.340

AMH (ng/ml)

1.09 (0.63, 1.74)

3.43 (2.22, 5.23)

< 0.001

1.45 (0.94, 2.13)

1.35 (1.01, 2.55)

0.270

Body mass index (kg/m2)

22.60 (20.80, 24.70)

22.71 (20.80, 25.03)

0.189

22.91 (21.13, 25.12)

22.88 (21.01, 24.93)

0.237

Cause of infertility, n(%)

< 0.001

 

0.956

 Tubal

810 (45.08)

376 (35.01)

145 (38.67)

133 (35.47)

 Male factor

251 (13.97)

106 (9.87)

29 (7.73)

35 (9.33)

 Anovulatory

57 (3.17)

39 (3.63)

35 (9.33)

42 (11.20)

 Unexplained

294 (16.36)

327 (30.45)

98 (26.13)

104 (27.73)

 Diminished ovarian reserve

304 (16.92)

181 (16.85)

40 (10.67)

39 (10.40)

 Endometriosis

66 (3.67)

40 (3.72)

22 (5.87)

16 (4.27

Mixed factors

15 (0.83)

5 (0.47)

6 (1.60)

6 (1.60)

Insemination method, n(%)

< 0.001

 

0.230

 IVF

916 (50.97)

714 (66.48)

229 (61.07)

250 (66.66)

 ICSI

818 (45.52)

320 (29.80)

133 (35.47)

111 (29.60)

 IVF + RICSI

63 (3.51)

40 (3.72)

13 (3.47)

14 (3.73)

  1. Data are presented as the median (25th and 75th percentile) or number (%). Mann‒Whitney U statistics were used for continuous variables and chi-square tests were used for categorical variables. There were no significant differences after propensity score matching.
  2. CC cotreatment clomiphene citrate and gonadotropin cotreatment, GnRHa gonadotropin-releasing hormone agonists, FSH follicle-stimulating hormone, LH luteinizing hormone, AMH anti-müllerian hormone, IVF in vitro fertilization, ICSI intracytoplasmic sperm injection, RICSI early rescue intracytoplasmic sperm injection.
Back to article page