Table 2 Logistic regression analysis of risk factors for CRKP BSI development.

From: High mortality associated with inappropriate initial antibiotic therapy in hematological malignancies with Klebsiella pneumoniae bloodstream infections

Variable

Univariate

Multivariatec

OR (95% CI)a

p valueb

OR (95% CI)a

p valueb

Neutropenia days ≥ 10

1.72 (0.94–3.13)

0.0782

1.35 (0.56–3.25)

0.509

Perianal infection

5.63 (1.99–15.95)

< 0.001

10.87 (2.64–44.84)

0.00096

Charlson comorbidity index score

1.41 (1.03–1.92)

0.03

0.89 (0.57–1.4)

0.612

Congestive heart failure

5.65 (1.8–17.8)

< 0.001

4.84 (1.07–21.85)

0.0404

Previous admission in ICU

7.78 (3.94–15.37)

< 0.001

2.03 (0.64–6.41)

0.229

Previous used mechanical ventilation

3.07 (1.34–7)

0.01

0.63 (0.13–2.99)

0.562

Pitt bacteremia score

1.24 (1.14–1.35)

< 0.001

1.02 (0.85–1.22)

0.817

Hypotension

9.06 (4.61–17.8)

< 0.001

4.04 (1.05–15.48)

0.0417

Hypoalbuminemia

5.18 (2.71–9.91)

< 0.001

2.49 (0.99–6.29)

0.0536

Empirical anti-infection treatment

 Carbapenems

8.33 (4.26–16.29)

< 0.001

5.81 (2.29–14.74)

0.00021

 Cephalosporins

4.46 (1.86–10.67)

< 0.001

1.74 (0.54–5.6)

0.35

 Tigecycline

4 (1.49–10.77)

0.01

0.73 (0.17–3.09)

0.671

 Fluoroquinolones

4.33 (2.08–9.04)

< 0.001

1.93 (0.73–5.06)

0.183

  1. aOR: Odds Ratio; CI: Confidence Interval.
  2. bp < 0.05 for significance.
  3. cThe Variance Inflation Factor (VIF) values are all relatively low, with none exceeding the common threshold of 10. The pseudo R-squared value is approximately 0.414.
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