Figure 5

Histological (H&E) and immunohistochemical (IHC) staining of male S. mekongi treated with different chemicals. Upper panel: H&E and IHC staining of untreated parasites illustrated internal structures, including the integument, parenchymal cells, and gut. Immunolocalization of phosphoserine in the parasites indicates the positive immunolabelling of liquid permanent red, mainly in the parenchymal cells and integument throughout the worm. Lower panel: comparative study of phosphoserine expression in the parasites treated with or without FAK inhibitors: DMSO, FAK inhibitor 14, PF-03814735, and PZQ. Phosphorylation is indicated by black arrows.