Figure 6
From: ACLS4 could be a potential therapeutic target for severe acute pancreatitis
ACSL4 Inhibitor PRGL493 Improves Severe Acute Pancreatitis in Mice. Group of DMSO- and PRGL493-treated mice were injected with arginine to induce severe acute pancreatitis. (A) Serum amylase levels (n = 5). (B) qPCR of IL-1β, IL-6 and TNF-α mRNA levels in pancreas (left) and spleen (right) (n = 5). (C,D) representative H&E staining of pancreatic sections with pathology scores (C) H.E. staining of pancreas. (D) Pancreatic pathology scores. Arginine-induced SAP mice were administered with DMSO or PRGL493. (E) Serum amylase levels (n = 5). (F) qPCR of ACSL4, IL-1β, IL-6 and TNF-α mRNA levels in pancreas (left) and spleen (right) (n = 5). (G,H) Representative H&E staining of pancreatic sections with pathology scores (G) H.E. staining of pancreas. (H) Pancreatic pathology scores. P values were determined by unpaired two-tailed Student’s t-test; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.
