Figure 6

Diffusion tensor imaging measurements of fractional anisotropy of TBI and TBI-naltrexone treated mice. t-statistical maps of whole brain diffusion tensor imaging showing differences in FA at 8 days and 3 months post-TBI. Images are overlaid onto the Waxholm template image with the mean FA skeleton shown in green. Statistics were calculated using a randomized algorithm from FMRIB software library (FSL), with 252 possible permutations and threshold-free cluster enhancement (TFCE). The images were thresholded at p < 0.05 (n = 5), with significant decreases in FA shown in blue. Abbreviations: diffusion tensor imaging (DTI); fractional anisotropy (FA); tract-based spatial statistics (TBSS). TBI traumatic brain injury, T + N TBI with naltrexone.