Figure 8
From: Neuroprotective effects of naltrexone in a mouse model of post-traumatic seizures
TBI model and naltrexone treatment regimen. Experimental design illustrating non-telemetry (experiment I, without implants) and telemetry (experiment II, with implants) groups, and detailing their respective treatment regimens and endpoints. For non-telemetry animals, traumatic brain injury was induced on day 1 (D1) and the PTZ-test was performed on day 2, whereas for telemetry animals, the PTZ-test was performed on day 5 post-TBI, i.e., after the electrode implantation (day 2). Naltrexone treatment was initiated 2 h after administration of the sub-convulsive dose of PTZ. The monitoring of the spontaneous seizures (experiment II) started three weeks after TBI. Animals were euthanized at 8 d (for experiment I) and 3 month (for experiment II) post-TBI.
